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Endometriosis - How preventive biology can help?

 ENDOMETRIOSIS

 Endometriosis is a complex syndrome characterised by a chronic inflammatory process due to the presence of tissue similar to the uterine lining outside the uterus.

This "ectopic uterus" continues to function under the influence of ovarian hormones, causing severe pain and sometimes infertility in some women.

One woman in 10 is affected by a form of endometriosis

The reflux of endometrial cells at the time of menstruation, which occurs in 90% of women, is the preferred theory to explain endometriosis. However, only 10% of them develop a pathology.

Today, little is known about the causes of endometriosis, its natural course and the factors that influence its progression.

Identifying the causes for better treatment:

A review of the literature published in August 2018 provided the following non-exhaustive picture of the causes of the pathology: low birth weight, early onset of the first menstrual period, low BMI, short menstrual cycles, hyperostrogenism. Recently, nutritional and environmental factors have been studied in greater depth.

In addition, the hyperpermeability of the mucosal barriers may explain the passage of endometrial cells to other organs.

Several studies have shown an increase in oxidative stress in the serum of women with endometriosis. Oxidative stress is a very general mechanism inducing and caused by inflammation.

The survival of endometriotic cells outside the uterus could be related to a malfunctioning of the immune system such as macrophages and B cells resulting in chronic local inflammation, and a failure to eliminate these ectopic cells.

Before considering treatment, the first step is to reduce the time taken to diagnose endometriosis, which is currently estimated to be between 7 and 10 years after the first symptoms appear.

Currently, drug treatment, surgery and assisted reproduction (AMP) are the only 3 existing approaches to treat the symptoms of endometriosis and its possible consequences on fertility.

The Physiological Nutrition Clinic offers several check-ups that will enable us to objectively highlight the various imbalances in order to provide an individualised response to each patient.

The oxidative stress assessment: when a cell is attacked or inflamed, it produces a large quantity of free radicals. Antioxidant enzymes are one of the first lines of defence against these free radicals. They require minerals such as copper or selenium, which are called co-factors, to function.

If you don't have the necessary reserves of co-factors you won't be able to defend yourself against free radicals and this will create major damage (such as a DNA transcription error that can lead to poor cell elimination, poor hormonal communication, cancer).

Nutritional assessment: many studies show the interest of nutrition in the management of endometriosis from different points of view:

Control of oxidative stress as we have just seen.

Control of inflammation: we know, for example, that the intensity of the inflammatory response depends on the membrane balance of your fatty acids (the PAGE) and certain vitamins.

Efficiency of the immune response: certain vitamins and minerals are essential for the proper functioning of the immune response. A sufficient supply of these elements is therefore necessary.

Handling of endocrine disruptors: the thyroid function is largely responsible for handling the various pollutants that we absorb. And it is these pollutants that, if not taken care of, will have an impact on hormonal communication and inflammation. For this the thyroid needs sufficient iodine and selenium. 

Immune and inflammatory assessment: This assessment will show you how your body deals with inflammation. Inflammation is a reaction that is part of the immune response that occurs depending on the stimulus and its intensity. An unbalanced immune system will result in a disproportionate, chronic immune and inflammatory response.

The microbiota and AGCC assessment: at first sight you might say: what is the relationship between our gut microbiota and endometriosis? Very recent studies show that your microbiota will play a very important role in the management of your endometriosis:

         1-it is your intestinal microbiota that largely educates your immune system. As we have just seen, a poorly educated immune system will produce an inappropriate response, such as inflammation of the intestines.

2-it is your intestinal microbiota that ensures the integrity of your mucous membranes and their barrier function. In the case of endometriosis, the mucous membranes are damaged and the hyperpermeability is partly responsible for the presence of endometrial cells outside the uterine cavity.

         3- A relationship has been established between too many pathogenic bacteria in your gut microbiota and endometriosis. By knowing these bacteria (which are unique to each of you), you can fight them more effectively.

         4- your intestinal microbiota is capable of producing real natural medicines (the AGCC) as well as numerous vitamins capable of acting at the digestive level but also at a distance.

         5- your microbiota plays a role in regulating the level of circulating oestrogen: an unbalanced microbiota can cause an increase in the level of circulating oestrogen and therefore increase the severity of endometriosis.

 Treatments:

-Oxidative stress assessment in endometriosis                                                          £165 *

-Endometriosis nutritional assessment                                                                    £257 *

-Endometriosis immune and inflammatory assessment                                          £267 *

-Intestinal microbiota assessment + AGCC                                                              £353 *

*price including analysis and transport costs (LIMS laboratory (Belgium)) excluding consultation

If you would like to have a combination of all these tests, please contact us: 

Sébastien JEAN

Nutrition and preventive biology

contact@nutrition-physiologique.com

www.nutrition-physiologique.com