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Why Measure Your Bile Acids?

 

Do you suffer from any of these conditions?

-pain and/or chronic discomfort centred on the stomach area with a feeling of heaviness, "overflow" or bloating accompanied by eructation (belching).

-chronic transit disorders (diarrhoea or constipation) that are resistant to all treatments.

-gallstones

-chronic inflammatory bowel disease

-intolerance to any drug treatment

-chronic hypo- or hypercholesterolemia

-vitamin A or E or D or K deficiency that is resistant to all forms of supplementation

-unexplained increase in your gamma GT

-poly-articular pain

-retinal disease

-family history of Alzheimer's disease

- recurrent herpes

- Fragile to the influenza virus

-cholestasis with its intense pruritus (itching sensation) which appeared during your 2nd or 3rd trimester of pregnancy.

 

In this case the problem may be with your bile acids and there are solutions to remedy this.

WHAT DO WE MEASURE?

1- PRIMARY BILE ACIDS AND CONJUGATED BILE ACIDS

IN THE LIVER, primary bile acids are made from cholesterol and stored in the gallbladder to be excreted in the intestine at the beginning of meals to allow digestion and absorption of fat-soluble nutrients.

They are then reabsorbed in the terminal ileum to return to the liver via the portal vein.

In the liver, the primary bile acids are transformed into secondary bile acids, thanks to two amino acids, glycine and taurine, in order to make them less toxic for the liver.

Conjugated bile acids are stored in the gallbladder and excreted into the intestine with the primary bile acids.

 

2- SECONDARY BILE ACIDS

AT THE INTESTINAL LEVEL, a small part of the primary bile acids do not return to the liver and are transformed into secondary bile acids thanks to enzymes produced by certain bacteria in the intestinal microbiota.

 

WHAT ARE THE ROLES OF BILE ACIDS?

Bile acids have receptors throughout the body, particularly in the intestines, kidneys, lungs, brain and bones.

Their roles, often underestimated, are numerous:

  1. They ensure the digestion and assimilation of fat-soluble nutrients:

These are fatty acids, vitamins A, E, D, K, carotenoids and phytosterols.

Poor digestion and assimilation of fat-soluble nutrients can lead to a deficit with repercussions on health.

For example, a vitamin D deficiency will lead to significant cardiovascular risks, colorectal cancer risks, and predisposition to viral and bacterial infections.

  1. Regulate the amount of water in the digestive tract:

If you are chronically constipated or on the contrary if you have permanent diarrhoea, the problem may come from your bile acids because they regulate the absorption of sodium and liquid secretions in the colon.

  1. Keep your intestinal barrier tight:

By regulating the proliferation and death of intestinal cells, bile acids prevent intestinal hyperpermeability, which is responsible for digestive disorders and remote disorders such as migraines, joint pain etc. etc.

  1. Ensures liver detoxification

Bile acids allow the elimination of hepatotoxic compounds and therefore avoid the clinical signs of liver fatigue (nausea, headaches, etc.) as well as pathologies that can affect the liver (inflammation, cirrhosis, cancer).

  1. Regulate the metabolism of carbohydrates, lipids and cholesterol:

Bile acids therefore help prevent metabolic disorders that can lead to diabetes and/or obesity.

  1. Modulate immunity: better antibacterial and antiviral defence

Bile acids allow us to have an adapted response to a virus or bacterial infection by intervening directly on the immune system but also indirectly through the action on the intestinal microbiota.

  1. Prevention of osteoporosis

As we know today, bile acids are able to bind to the bones.

An imbalance in their synthesis will be a factor in osteoporosis and fractures.

  1. Regulation of serotonin

Serotonin is the happiness hormone. Most of it is secreted in the intestine and its level is regulated by secondary bile acids.

Any imbalance in the synthesis of secondary bile acids can lead to mood disorders.

  1. Special role of ATUDC conjugated bile acid:

This bile acid is said to have a protective effect against neurodegenerative diseases (Alzheimer's) but also against retinal degeneration.

It is also able to inhibit the influenza A virus and modulate the herpes virus.

  1. Bile acids and pregnancy

An imbalance of bile acids can cause a disorder in the excretion of bile during pregnancy.

It is also the bile acids of the newborn that allow the correct maturation of its intestinal microbiota.

 

WHAT TREATMENTS ARE AVAILABLE?

Whatever your state of health, it is important to balance bile acid synthesis.

Your analysis results will allow us to determine precisely which bile acids (primary, secondary or conjugated) are in excess and/or in deficit, to propose an individual treatment and to follow the evolution of this treatment thanks to a check-up.

 

Sébastien JEAN

Nutrition et biologie préventive

Clinique de nutrition physiologique

contact@nutrition-physiologique.com

www.nutrition-physiologique.com